Objectives

• Recognize the regulatory role of the U.S. Food and Drug Administration in blood banking and transfusion services.

• Identify the U.S. Food and Drug Administration division responsible for regulating blood and blood components.

• Name the organization that develops standards and accreditation programs for blood banks and transfusion services.
• Identify the organization responsible for accrediting hematopoietic progenitor cell transplantation and cellular therapy programs.

• Identify the organization that requires employers to inform employees of workplace standards and post literature that advises them of their rights and responsibilities.

• Define terms associated with quality and operational policies, processes, and procedures (PPP).

• Identify the recommended quality control frequency for critical blood bank equipment and reagents.
• Name the process that establishes documented evidence that a specific process consistently produces a product meeting its preestablished quality and performance specifications.
• Identify the transfusion complication that may be mimicked by overheating blood during transfusion.

• Identify the blood component with the greatest risk of transfusion-related bacterial contamination.
• Name the agency that should be informed of a biological product deviation (BPD).

 Objectives

The participant will:

• Identify the most immunogenic class of molecules.
• Name the lymphocytes responsible for humoral immune responses.
• Recognize the basic structural composition of an immunoglobulin molecule.
• Specify the process by which antibody-coated red blood cells are cleared by the liver and spleen.
• Identify the immunoglobulin most efficient at activating the classical complement pathway.
• State the region of the IgG molecule responsible for placental transport.
• Recognize the process responsible for enhanced antibody responses following repeated antigen exposure.
• Indicate the factors that determine the overall strength of antigen-antibody binding.

• Distinguish between serum and plasma in a centrifuged blood specimen.
• Recognize why matching for the D antigen is important when selecting donor red blood cells for transfusion.
• Name the blood group system whose clinically significant antibodies are primarily IgM.
• Identify the complement component responsible for intravascular red blood cell lysis.
• Indicate the complement protein that functions as a chemotactic factor for platelets and neutrophils.
• Name the organ responsible for removing damaged red blood cells and clearing antigen-antibody complexes from the circulation.
• Indicate the action that enhances weak IgM reactions during ABO reverse grouping.
• Specify the optimal concentration of red blood cell suspensions for standard manual tube testing.
• Match agglutination reaction grades with their corresponding serologic findings.
• Recognize when a hemolyzed specimen should be rejected for compatibility testing.
• Identify the routine blood bank test used to detect unexpected antibodies to non-ABO red cell antigens.