Part I. Introduction to Hematology

1. An Overview of Clinical Laboratory Hematology

2. Patient Safety in Hematology and Hemostasis

3. Quality Assurance in Hematology and Hemostasis Testing

Part II. Blood Cell Production, Structure, and Function

4. Cell Structure and Function

5. Hematopoiesis

6. Erythrocyte Production and Destruction

7. Erythrocyte Metabolism and Membrane Structure and Function

8. Hemoglobin Metabolism

9. Iron Kinetics and Laboratory Assessment

10. Leukocyte Development, Kinetics, and Functions

11. Platelet Production, Structure, and Function

Part III. Laboratory Evaluation of Blood Cells

12. Manual, Semiautomated, and Point-of-Care Testing in Hematology

13. Automated Blood Cell Analysis

14. Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

15. Bone Marrow Examination

Part IV. Erythrocyte Disorders

16. Anemias: Red Blood Cell Morphology and Approach to Diagnosis

17. Disorders of Iron Kinetics and Heme Metabolism

18. Anemias Caused by Defects of DNA Metabolism

19. Bone Marrow Failure

20. Introduction to Increased Destruction of Erythrocytes

21. Intrinsic Defects Leading to Increased Erythrocyte Destruction

22. Extrinsic Defects Leading to Increased Erythrocyte Destruction—Nonimmune Causes

23. Extrinsic Defects Leading to Increased Erythrocyte Destruction—Immune Causes

24. Hemoglobinopathies (Structural Defects in Hemoglobin)

25. Thalassemias

Part V. Leukocyte Disorders

26. Nonmalignant Leukocyte Disorders

27. Introduction to Hematologic Neoplasms

28. Flow Cytometric Analysis in Hematologic Disorders

29. Molecular Diagnostics in Hematopathology

30. Cytogenetics

31. Acute Leukemias

32. Myeloproliferative Neoplasms

33. Myelodysplastic Neoplasms

34. Mature Lymphoid Neoplasms

Part VI. Hemostasis and Thrombosis

35. Normal Hemostasis

36. Hemorrhagic Disorders and Laboratory Assessment

37. Qualitative Disorders of Platelets and Vasculature

38. Quantitative Disorders of Platelets: Thrombocytopenia and Thrombocytosis

39. Thrombotic Disorders and Laboratory Assessment

40. Antithrombotic Therapies and Laboratory Assessment

41. Laboratory Evaluation of Hemostasis

42. Hemostasis and Coagulation Instrumentation

Part VII. Hematology and Hemostasis in Selected Populations

43. Hematology and Hemostasis in the Pediatric, Pregnant, Geriatric, and Transgender Populations

Patricia L. James, MA, Content Expert

Pat James earned her bachelor’s degree in Medical Technology from Jacksonville University in Jacksonville, Florida and a Master of Arts in Health Care Administration and Supervision at Central Michigan University in Mt. Pleasant, Michigan. She has 20 years’ experience in the field of Medical Technology, including hematology, chemistry, microbiology and blood banking. This experience has included bench technologist and supervisory positions in various health care settings, such as acute care and specialty hospitals and physician offices. Additionally, she has 20 years’ experience in state and federal clinical laboratory governmental regulatory programs (CLIA) at both the inspector and administrative level. 

Mary Weinstein, MS, MT(ASCP), Editor

Mary Weinstein earned her BA in Biology from Carlow College in Pittsburgh, Pennsylvania; her Certificate in Medical Technology from Mercy School of Medical Technology in Pittsburgh; and a Master of Science in Medical Technology (with specialization in Medical Microbiology) from West Virginia University in Morgantown, West Virginia. She is also certified as a Medical Technologist by the American Society for Clinical Pathology. She has over 25 years of experience in the field of Medical Technology, including hematology, microbiology, and chemistry. She has held positions as a bench technologist, instructor in hospital, industry and university settings, and laboratory inspector for state and federal laboratory licensure programs.