Serology/Immunology (2 Hours)

Author:
Publisher: F.A. Davis Company
Date Published: 2021
Pages: 15
Cover Type: Soft Cover
Expiration Date: 12/31/2023

Introduction to Cytokines

  • Define cytokine.
  • List effects of cytokines on many different cell types in the immune response.
  • Distinguish between the properties of cytokines.
  • Differentiate between the terms used to classify cytokine signaling activity.
  • Name the term that describes the massive overproduction and dysregulation of cytokines with extremely high circulating levels of proinflammatory cytokines.

Cytokines in the Innate Immune Response

  • Identify the process that induces production and secretion of inflammatory cytokines in response to infection caused by pathogenic bacteria and fungi invading the body’s epithelial barriers.
  • Explain the functions of Interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in mediating the immune response.
  • List the purposes of higher body temperatures during infection.
  • Specify the effect of the cytokine interleukin-1RA (IL-1RA).
  • Distinguish between the cytokines that comprise the tumor necrosis factor superfamily.
  • Specify the activity of interleukin-6 (IL-6) in the immune system.
  • Determine the role of chemokines in the chemotaxis of white blood cells (WBCs).
  • Identify the cytokine which acts primarily as a regulator of cell growth, differentiation, apoptosis, migration, and the inflammatory response, acting as a control to help downregulate the inflammatory response.
  • Identify the activity of the type I interferons IFN-α and IFN-β.

Cytokines in the Adaptive Immune Response

  • Explain the role of the cytokines expressed by T cell helper 1 (Th1) cells in the immune process.
  • Explain the role of the cytokines expressed by Th2 cells (IL-4 and IL-10) in the immune process.
  • Specify how T regulatory cells (Tregs) in the immune system may be identified.
  • Identify the essential role of Tregs.

Th17 Cytokines in Innate and Adaptive Immune Responses

  • Describe the role of Th17 cells in the host immune response.
  • State the possible effects of dysregulation of Th17 cell subsets and secreted cytokines.

Hematopoietic Growth Factors

  • Explain the biological role of activated macrophage colony-stimulating factor (M-CSF).

Cytokine and Anti-cytokine Therapies

  • State the purpose of anti-cytokine therapies.

Clinical Assays for Cytokines

  • Distinguish between clinical assays for cytokines.
  • Introduction to Cytokines
  • Cytokines in the Innate Immune Response
  • Cytokines in the Adaptive Immune Response
  • Th17 Cytokines in Innate and Adaptive Immune Responses
  • Hematopoietic Growth Factors
  • Cytokine and Anti-Cytokine Therapies
  • Clinical Assays for Cytokines

Meets Florida 1-hour specialty requirement in serology/immunology

“Cytokines” discusses the different types of cytokines and their functions and interactions in both innate and adaptive immune systems in response to infection. The chapter also explains “cytokine storms” seen in patients with COVID-19.

"Cytokines" is Chapter 6 of Clinical Immunology and Serology: A Laboratory Perspective, 5th edition, by Linda E. Miller, PhD, I, MBCM(ASCP)SI, et al. Published by F.A. Davis Company in 2021.

 

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