Accurate Results in the Clinical Laboratory
Dasgupta, PhD, DABCC, and Sepulveda, MD, PhD
340 plus index
Expiration Date: 12/31/2018
Section A, worth 12 contact hours, satisfies the Florida 1-hour specialty requirements in clinical chemistry and administration/supervision. For those certified by ASCP, Section A provides 11 contact hours in clinical chemistry and 1 hour in administration/supervision.
Section B, worth 15 contact hours, satisfies the Florida 1-hour specialty requirements in clinical chemistry, immunohematology, hematology, molecular pathology, immunology/serology and microbiology. For those certified by ASCP, Section B provides 7 contact hours in clinical chemistry, 2 hours in immunohematology, 2 hours in hematology, 2 hours in molecular pathology, 1 hour in immunology/serology and 1 hour in microbiology.
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Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction is intended as a guide to increase the awareness of both clinicians and laboratory professionals about the various sources of errors in clinical laboratory tests and actions which can be taken to minimize or eliminate such errors.
Section A quiz (Chapters 1-10): Chapter 1 addresses various sources of preanalytical errors and discusses the scope and type of errors in the clinical laboratory and quality assurance measures taken to minimize them. Chapter 2 presents the effects of gender, ethnicity, age, diet and exercise on laboratory test results, and Chapter 3 discusses the effects of patient preparation and specimen collection on laboratory results. Chapter 4 reviews specimen misidentification and specimen processing issues.
Various endogenous substances such as bilirubin, lipids, and hemolysis affect many laboratory test results, and this issue is discussed in Chapter 5. Chapter 6 discusses various immunoassay formats with an emphasis on the mechanisms of interference of heterotrophic antibodies and autoantibodies, and reviews general approaches to eliminate such interference.
Many Americans use herbal supplements, some of which may affect clinical laboratory test results. In addition, certain herbal supplements may cause organ damage, and an unexpected laboratory test result may be the first indication of such organ toxicity. Chapter 7 discusses in detail the effects of herbal supplements on laboratory results.
Chapters 8 and 9 present sources of errors in measuring common analytes in clinical chemistry; Chapter 10 presents sources of errors in biochemical genetics.
Section B quiz (Chapters 11-21): Issues concerning various hormones and endocrinology testing are reviewed in Chapter 11, and Chapter 12 is devoted to challenges in measuring cancer biomarkers.
Therapeutic drug monitoring, drugs of abuse testing, and alcohol testing are major functions of toxicology laboratories, and there are many interferences in the test methodologies used to detect these analytes. These issues are discussed in Chapters 13-16 with an emphasis on various approaches to eliminate or minimize such interferences.
Chapter 17 addresses critical issues in transfusion medicine and Chapter 18 presents sources of errors in hematology and coagulation. Chapter 19 briefly discusses challenges in immunology and serology testing, and sources of errors in microbiology testing and molecular testing are presented in Chapters 20 and 21, respectively.
Accurate Results focuses primarily on sources of error and error correction in the areas of clinical chemistry, including routine chemistry, endocrinology, and toxicology, discussing various methodologies in great detail. Much less detail is presented in the areas of hematology, microbiology and serology. Therefore this book will be of primary interest to laboratory personnel working in the areas of clinical chemisty, but to this group, the book should be a valuable resource.
This course is advanced.